Assassin's Creed: Brotherhood

The plot is set in a fictional history of real-world events and follows the millennia-old struggle between the Assassins, who fight to preserve peace and free will, and the Templars, who desire peace through control. The framing story is set in the 21st century and features series protagonist Desmond Miles who, using a machine known as the Animus, relives the memories of his Assassin ancestor, Ezio Auditore da Firenze, to find a way to avert the 2012 apocalypse. The main story takes place during the Italian Wars, spanning the years 1500–1507, and continues from the events of Assassin's Creed II, as Ezio takes the fight against the Templars (led by the powerful Borgia family) to Rome, where he attempts to rebuild the Assassin Brotherhood in Italy and liberate the city from the Borgias' control.

Blind playthrough. I did some of the side stuff.